Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans.
نویسندگان
چکیده
Parallels between T cell kinetics in mice and men have fueled the idea that a young mouse is a good model system for a young human, and an old mouse, for an elderly human. By combining in vivo kinetic labeling using deuterated water, thymectomy experiments, analysis of T cell receptor excision circles and CD31 expression, and mathematical modeling, we have quantified the contribution of thymus output and peripheral naive T cell division to the maintenance of T cells in mice and men. Aging affected naive T cell maintenance fundamentally differently in mice and men. Whereas the naive T cell pool in mice was almost exclusively sustained by thymus output throughout their lifetime, the maintenance of the adult human naive T cell pool occurred almost exclusively through peripheral T cell division. These findings put constraints on the extrapolation of insights into T cell dynamics from mouse to man and vice versa.
منابع مشابه
Be fruitful, multiply, and replenish.
Because the size of the thymus in children is much larger than in adults, thymus output is widely believed to be responsible for the development of the peripheral T-cell pool during childhood. This idea is strengthened by the associations between age and the rate of T-cell reconstitution in lymphopenic patients,1 and between thymus involution and decreasing naive T-cell numbers per microliter o...
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عنوان ژورنال:
- Immunity
دوره 36 2 شماره
صفحات -
تاریخ انتشار 2012